“一见钟情”的事似乎经常会发生在一些年轻男女的身上。这一点对于身为艺术品经销商的布鲁克(詹妮弗·安妮斯顿)和经营运输业的盖瑞(文斯·沃恩)也相当奏效。两人经过似乎上天注定的一见钟情之后，很快便投入到婚姻的殿堂中，并迅速合伙贷款买了栋相当气派容光的大房子，共同搭建起两人的爱巢。但俗话说“相爱容易相守难！”两人一起浪漫缠绵的日子没过多久，便渐渐因生活中的琐事产生了许多无可避免的矛盾冲突。美丽直爽的布鲁克面对眼前这个曾给予自己多少浪漫情调的大男人终于看到了让自己无法忍受的诸多坏毛病。而期望在另一半那里找寻理解和关爱的盖瑞也感觉到和女人相处并非当初想象的那么容易。于是，在经历了几番争吵和打闹之后，两人决定好聚好散。然而，两人对于分手后房子的归属却有了很大的分歧。布鲁克坚持之后的分期付款完全由自己负担，并全面占有这所大房子，还要求盖瑞马上卷行李走人。而一向大男子主义自居的盖瑞当然无法接受这样的无理条件了。他认为马上离开的应该是布鲁克。双方坚持不下，于是两人都赌气地继续同住在这所大房子里，想尽一切办法将对方从这里弄走。布鲁克和盖瑞于是便展开了一场“分手斗气之争”。这对冤家各自出尽各种怪招企图逼对方就范。布鲁克更是广征密友，期望在和其他男人的亲密接触中，气走可恨的盖瑞。从心理医生到曾经的亲密好友，甚至毫不相识的陌生人都成了她达到目的的工具。另一方面，盖瑞也施展各种招数应付着，经历几次“交火”之后，双方始终是争持不下。此时，布鲁克和盖瑞两人都慢慢察觉到，原来自己一直以来在争夺的并不是什么房子的所有权，而就是眼前这个始终爱自己在乎自己的人……
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