突厥吉利可汗的寿辰将至，武则天派遣狄公的左膀右臂李元芳及曾泰组成一支使团赴突勒赐婚，祝寿品为由本朝金银器大师，殿中省将作大监波斯人沙尔汗亲手制成的海兽戏波大盘，但是善金局被劫，一百万两金银失踪，二十三名银匠失踪，狄仁杰受命，调查出了幕后凶手竟是沙尔汗，将其抓获，不想沙尔汗饮毒药自尽，更令人惊讶的是—...—沙尔汗的妻子说这并不是沙尔汗！案情陷入僵局。
千牛卫大将军李元芳率赐婚使前往突勒，以及将案件同党送往，不料遭遇一只神秘军队突劫。同时朝中狄仁杰被人陷害，武则天将他软禁在府中，准备将其打入天牢，狄仁杰不得不潜逃。李元芳则冲出突勒，准备禀告狄公。李元芳来到凉州，看到两国战火已起，不得不禀告狄仁杰，大将军王孝杰说狄公已潜逃。此时狄仁杰前往月氏国，发现已被吐火罗人占领，最终赶走了吐火罗人。不料月氏国国王神秘死亡，最终狄仁杰进行一番调查，查处了朝中叛党将其抓获。
《神断狄仁杰》又称《神探狄仁杰4》，分为《金银奇案》和《杀人陷阱》两个扑朔迷离、案情愈演愈烈的故事组成。《金银奇案》讲述突厥吉利可汗的寿辰将至，武则天（吕中饰）派遣狄仁杰（梁冠华饰）的左膀右臂李元芳（张子健饰）及曾泰（须乾饰）组成一支使团赴突厥祝寿，然而却牵扯出一宗举朝震惊的黄金失窃案。《杀人陷阱》则讲述月氏国人与吐火罗人之间的生死较量。 本部历史侦探悬疑系列电视剧《神探狄仁杰》，已有四部推出，部部故事悬念迭出，情节扣人心弦，《神探狄仁杰5》也即将在2014与观众见面。《神探狄仁杰》系列电视剧不仅融合扑朔迷离的悬疑剧情与恐怖的视觉元素为一身，更加入了李元芳与狄如燕的爱情、狄仁杰与曾泰的师生之情、以及武则天与狄仁杰的君臣际遇等情感戏码，使得本系列电视剧在惊险刺激的段段案件中增添了不少温情色彩。
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