《最美的安排》由北京悦圣龙影视传媒有限公司、上海玉晶影业有限公司出品，著名导演刘国权执导，李冲担任编剧，范明、颜丹晨、张大静、温玉娟，王建新等联袂主演的现代都市轻喜剧.潘大为（范明饰）的妻子杨冰去世多年。杨冰孪生妹妹杨清从国外归来，想要找回当年遗弃的孩子，而这个孩子就是潘大为的女儿潘朵拉。潘大为不许杨清告诉孩子真相，杨清便以二姨的身份跟潘朵拉建立了深厚的感情。杨清想偷偷带潘朵拉出国，被潘朵拉发现真相，与杨清断绝关系。
杨清为了得到潘朵拉的原谅，决定跟潘大为结婚，遭到潘朵拉和家人反对。杨清失落，准备离开。潘大为让女儿看了杨清为潘朵拉准备的一切，潘朵拉体会到母爱，母女相认。岳母张翠兰记恨杨清当年抛家弃子，不认杨清。潘大为让杨清装扮成杨冰的模样，向张翠兰认错悔过，张翠兰原谅杨清。杨清对潘大为好感倍增，建立了恋爱关系。潘朵拉的生父温一虎出现，要夺回杨清和潘朵拉，杨清摇摆不定，潘大为揭穿温一虎的阴谋，最终与杨清走到了一起。
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