明朝中叶，倭寇不断骚扰东南沿海，东瀛柳生一族辅佐德川家康之余亦要席卷中原武林。于是“东瀛霸刀”柳生（任达华 饰）杀入武林、所向披靡，亦要向中原武林第一高手“天剑”独孤无极（刘松仁 饰）挑战。独孤无极正要与新婚妻子梦青丝（杨紫琼 饰）成亲，却不得不为此事拖延。他向“鬼医”（吴孟达 饰）求助，遂用剧毒将...自己功力提高数倍。比武之日，独孤无极力战柳生，将其赶走，自己却被体内毒气错乱神经，以致糊涂杀死山庄里无数友人，并气走青丝。青丝自此男装打扮，化名独孤贞，杀尽天下负心人。 鬼医弟子吴通（张卫健 饰）为了逃避年纪比他大许多的未婚妻牛娃（郑裕玲 饰），成婚当日逃走，巧遇微服出游的天香公主（张曼玉 饰）和贴身侍卫（吴君如 饰），三人发生争执，此时独孤贞出现解围。而此时镇上却在传言梦青丝在妓院摆出迷魂阵召贤比武的香艳传闻，惊讶的独孤贞于是与吴通一起前去探个究竟......
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