恐怖的病毒在英伦三岛横行了半年后，确切的说是28周之后。终于在美国军方的帮助下最终被彻底消灭。然而，此时的英国境内，已经没有一人生还。而致命的病毒也因失去鲜活的载体而随之消亡——然而，这只是科学家们的观点，实际上病毒远比他们想象的更可怕。这时，骄傲的美国人也发出声明——对抗杀人病毒的战斗获得了胜利，并开始帮助盟友英国重建家园。
英国伦敦著名的希斯罗机场传来一阵巨大的轰鸣声，一架从美国飞来的运输机在希斯罗机场慢慢着陆。飞机刚一停稳，戴防毒面具的陆战队士兵便飞身迅速地冲下飞机，他们小心地观察机场四周的情况。迅速占领有利地形，确保安全后才给飞机上的乘客发出信号。很快，从飞机上下来一群平民。事实上，他们是在英国政府发出病毒传染警报之前离开英国的英国人，如今，这些俨然担负起重建家园任务的可怜人已经是地球上最后的英国人了。重建家园的工作刚刚开始，便有人报告说发现被病毒感染的幸存者，科学家们迅速出动，希望从幸存者身上提取血清研制对付病毒的疫苗。然而，新的灾难也就此降临——可怕的病毒并没有被完全消灭，反而在经受了打击之后变得更加强大。已经饱受摧残与折磨的人类将面临更加恐怖和凶残的杀戮……
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