大学生卡莉·琼斯(艾丽莎·库伯特饰)、佩姬·爱德华兹(帕里斯·希尔顿饰)以及几个朋友在一起驱车前往年度大学美式足球联赛的路途中，决定在野外露宿一夜，这将成为他们毕生中最后悔的一个决定。起先是在营地中，他们与一位神秘的卡车司机发生了冲突，另大家都产生了一丝不安，气氛也变得逐渐凝固起来。紧接着卡莉的男朋友韦德(贾德·帕达里克饰)与她头脑发热、性情刚烈的哥哥尼克(查德·迈克尔·莫瑞饰)也是火药味十足，卡莉为了令他们俩和睦相处，也被折腾的精疲力尽。 当第二天他们醒来的时候，发现他们的车似乎被人动过手脚。冒着车子搁浅的危险，他们接受了一个当地人的邀请，前往离营地最近的小镇安布罗斯寻找援助。这是一个阴森、黑暗并且令人毛骨悚然的小镇，地图上都无法找到此地，而且卡莉和朋友们发现镇上似乎根本没人居住。一到那里，他们就被安布罗斯的主要建筑-“杜蒂”的腊像馆所吸引，里面充满了栩栩如生的蜡像。但是很快，他们就发现了隐藏在蜡像馆背后的秘密，以及为何这些蜡像会看起来如此逼真的原因…… 原来在蜡像馆中所有的雕塑品都是由真人做成的！是由一个极其残暴的杀人魔将被害人身体做成的“人肉蜡像”。在发现了这个惊人秘密之后，他们就被杀人魔列为了下一个要追逐残杀的对象，躲在暗处的蜡像院魔王随时都有可能跳出来将他们一一弑杀。为了生存，卡莉和她的朋友们必须参与到这场血腥斗争中，并寻找一条逃出去的路。最终她们是否能幸运逃脱于杀人魔的手掌，还是成为蜡像馆中另几座永恒的“人肉蜡像”呢？
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