这是一个发生在高速公路上的残酷恐怖经历，相信看过这个故事之后，你可能永远都不会让想搭你顺风车的人上车……格蕾丝·安德鲁斯和吉姆·哈尔西是一对年轻的情侣，在学校放假的这段时间里，他们决定结伴自驾游，开车横穿整个美国。他们驾驶着1970年产的奥斯莫比442上了路，可是旅途并不若他们预计的那般愉快，没走出多远，两人就开始有了这样或那样的小磨擦。而他们不知道的是，这只是以后地狱般的噩梦的一个序曲而已。开车旅行的过程是漫长而无聊的，所以当格蕾丝和吉姆发现路边有人伸手想搭顺风车时，就载上了他，这样可以有效地减少两人争吵的空间。搭车的人自我介绍叫约翰·怀德，喜欢自顾自地喋喋不休，但是约翰透露出的信息越多，格蕾丝和吉姆就越觉得心惊胆战，直到约翰说到自己刚刚杀掉上一个被搭车的司机时，吉姆终于忍受不了了，将约翰赶下了车。 然而，不详的阴影并没有随着约翰下车而消失，反而加速了事态的发展，约翰如影随行地跟在他们身后，而新墨西哥州的警官不但不能帮助他们摆脱麻烦，反而将他们当成了通缉的要犯，格蕾丝和吉姆首先要做到的，就是战胜让人窒息的恐惧感，这样才可以有机会活命，从杀人犯手中逃脱。
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