该片是一部血腥的黑色喜剧电影。1957年一支探险队在苏门答腊岛西南部的骷髅岛捕捉了一只叫鼠猴的动物，当地土著人都很害怕鼠猴，因为只要被它咬过的人都会变成僵尸。探险队捉住一只鼠猴后把它卖给了新西兰惠灵顿动物园。
莱昂纳尔是一个老实的小伙子，他喜欢上了一个名叫帕奎塔的漂亮姑娘。但是莱昂纳尔的母亲薇拉却反对莱昂纳尔的这个女朋友。莱昂纳尔和帕奎塔去惠灵顿动物园约会，薇拉偷偷跟着他们，没想到她却意外地被那只鼠猴咬了一下。三天后，薇拉变成了僵尸。更糟的是，护士多塔薇姿、神父多克格拉德以及所有被薇拉咬过的人都变成了僵尸。为了隐瞒这件事，莱昂纳尔把僵尸都关在房子里养了起来。一时间，事情变得越发不可收拾。莱昂纳尔的舅舅列斯听说薇拉去世的消息后，前来索要遗产。莱昂纳尔看出了列斯的野心，但没办法只好把全部的遗产交给了列斯。当晚，列斯在薇拉的家中举行了狂欢派对，帕奎塔也在其中。不料，那些僵尸全都跑了出来，他们见到派对上的人就咬。结果，派对的人们全都变成了僵尸。最后，只剩下帕奎塔和莱昂纳尔没有被咬。愤怒的莱昂纳尔不得不用电转盘对付僵尸，一时间血肉横飞。在一番血腥杀戮之后，莱昂纳尔终于和帕奎塔相拥在了一起，有情人终成眷属。
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