一对夫妇买下牧场邻边木屋，正当他们要搬进新屋之际，一场戏剧化的恐怖攻击改写了他们的命运。地狱来的怪客强占了他们的小屋，阻断食物供给，彻底将他们与文明隔离，过着野蛮人般生不如死的生活。女主人丧失心智出卖灵魂，而屋主也几近崩溃极限，他们如何死里求生？一部超出想象的心理惊悚电影。一向上进的大学生亨利·拉萨姆（瑞恩·高斯林 Ryan Gosling 饰）突然扬言要自杀，心理医生山姆·福斯特（伊万·麦克格雷格 Ewan McGregor 饰）为了挽救亨利，开始对其进行治疗。奇怪的事情发生了，医生山姆发现亨利经常会说出一些 骇人听闻的语言，更加令人不安的是，这些预言竟然一一应验。究竟是什么神秘的力量在操控着亨利？生死一线，中间真的能够停留吗？在女友丽拉·库尔佩（娜奥米·沃茨 Naomi Watts 饰）的支持和帮助下，山姆能否找到答案，拯救一切？
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