故事发生在意大利，一位女性被指控涉嫌在一场驱魔仪式中，发狂般谋杀三个人，而她的女儿对事实有所疑惑，为了找出事情的真相，将亲自参与这一系列未经授权的驱魔过程。 很多人被一个恶灵附身；只有她是被多重恶灵附身！1989年，119接到由玛莉亚罗斯（苏珊·克萝蕾 Suzan Crowley 饰）打出的电话，她自首虐杀了3个人。20年后，她的女儿伊莎贝拉（费尔南达·安德拉德 Fernanda Andrade 饰）试着深入挖掘案发当晚的真相，因此前往探视被禁锢在义大利专门治疗犯罪精神病的圣堤诺医院的母亲，以便确认20年前发生的惨绝人寰事件的缘由，究竟是因母亲心智丧失或是当真被邪魔附身。伊莎贝拉聘请两位年轻驱魔师（赛门·克特曼 Simon Quarterman 与 伊凡·海慕特 Evan Helmuth 饰）利用结合科学和宗教的创新疗法治疗她母亲，迫使他们必须与附身在玛莉亚身上的四种邪恶灵体正面接触。
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