皮囊第四季/SKINS第四季以一个叫索菲亚的女孩的死亡开始的，在party上她无故自杀，让在场的所有人心里都有了阴霾。通过警方和学校的调查，库克被认为是卖给索菲亚摇头丸的罪魁祸首，被关进了监狱，在监狱中Effy曾看望他，并告诉他，自己爱的是Freddie。库克最终选择了越狱先后逃到了内奥米家，小木屋，和JJ家中。在Fre...ddie失踪之后，Freddie的姐姐卡伦找到库克让他找Freddie。警方到内奥米家中逮捕库克，库克又逃到小木屋中，恰巧effy也在，随后JJ，Pandora，卡伦和其他人都也来到小木屋。库克出去尿尿时发现有陌生人，就跟踪他到仓库，在仓库发现Freddie的衣服和约翰，顿时明白一切，与约翰动手打了起来。
Effy的精神状况出现了问题，Freddie带Effy出去玩，但是Effy又出现的症状，最后EFFY被送进精神病院接受治疗，Effy的医生约翰爱上了她，用催眠让effy忘记以前，刚开始effy有好转的迹象。在公布成绩的patry上effy向大家宣布自己要离开，离开所有的人包括Freddie。库克受Freddie之命看望effy，但effy似乎不认识库克，在马路上effy受到惊吓又恢复一些痛苦的回忆。effy决定不再见约翰大夫，Freddie去找约翰时被约翰反锁至地下室，暴打而死。
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