《金枝欲孽2》讲述另一个时空、另一个后宫、另一番截然不同的“金枝欲孽”风貌，陈豪在剧中饰演御医，邓萃雯继续做如妃，蔡少芬则扮演邓萃雯的贴身侍女，两人最后由[1]主仆变敌人，有不少对手戏。但让人感觉可惜的是，该剧主演阵容中只列有陈豪、邓萃雯及蔡少芬，并未见上辑中讨观众喜爱的“孙白扬”林保怡、佘诗曼、黎姿及张可颐等，也没有与他们级数相当的艺人顶上，第二辑的演员阵容明显逊色于第一辑。相关资料 明年暂定开拍的《金枝欲孽Ⅱ》本来亦是可观之作，只是林保怡与佘诗曼等要角纷纷到内地发展，故要原班人马开拍续集机会渺茫。无线仍锲而不舍向外招手，电影演员更是招揽旗下的对象，不过无线想打“亲情牌”令昔日爱将回巢，此计暂时未能奏效。在内地身价达16至20万人民币1集的林保怡，外间一直对这位剧中“灵魂人物”会否接拍《金枝欲孽Ⅱ》甚为关注，但因为价钱问题，最终亦未能成事。如今落实接拍《金枝Ⅱ》的只有邓萃雯及陈豪 。
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