本片是根据路易斯·邓肯的小说改编而成。16岁的安迪和弟弟布鲁斯本是孤儿，收养他们的家庭有一项严厉的禁令就是“不准养宠物”，安迪于是不得不为他们取名叫“星期五”的狗狗再赶快找一个新家。偶然间，孩子们发现了一座地处偏僻已经废弃的旅馆，他们因此打算把“星期五”寄存在这里。姐弟俩叫来了朋友，把旅馆重新收拾整理了一下，狗狗就此入住了。没多久，周围的其他流浪狗渐渐“慕名而来”，狗狗越来越多。于是孩子们运用聪明才智，发明创造了一系列方便、实用但又很搞笑的自动装置，很快，这里便成了“流浪狗之家”。但是，这也引起了城市里警察的注意，他们逐渐查到了这个地方。孩子们为了保护狗狗打算将其转移，可是这么多狗如何能顺利转移出去？一场斗智斗勇大战就要开始了……
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